Clinical Insights

Evidence-based commentary, trial updates, and clinical briefings — written for healthcare professionals and informed patients.

For Patients Plain-language guides to understanding your condition and trial options

For Clinicians Evidence reviews, methodology commentary, and trial updates

Statins and Ibrutinib in CLL/SLL: Emerging Evidence for Combination Therapy

The observation that CLL cells are unusually dependent on cholesterol metabolism has generated sustained interest in whether HMG-CoA reductase inhibitors — statins — might enhance the activity of BTK inhibitors such as ibrutinib. This article reviews the mechanistic rationale, summarises the available preclinical and early clinical data, and explains the design of our KCLG-HAEM-01 Phase II trial.

For clinicians managing patients with relapsed/refractory CLL on ibrutinib, the potential for a well-tolerated, widely available adjunct therapy makes this a clinically important question — one we are now formally testing.

Read Full Article Dr [Name] · Haematology Lead · June 2025 · 8 min read

For Clinicians

Evidence Reviews & Trial Commentaries

In-depth analysis for healthcare professionals — methodology, trial design, and clinical implications.

Clinical trial pre-specification methodology

For Clinicians

Pre-specification in Clinical Trials: Why It Matters and How We Do It

An explanation of how pre-specified statistical analysis plans prevent selective reporting and protect the integrity of trial findings — with examples from our methodology.

April 2025 · 6 min Read →

For Clinicians

Adaptive Platform Trial Design: A Practical Guide for Clinician-Investigators

How adaptive designs improve efficiency without sacrificing rigour — covering master protocols, response-adaptive randomisation, and interim analysis rules.

March 2025 · 9 min Read →

For Clinicians

Metabolic Risk and Haematological Malignancy: What the Epidemiological Data Tell Us

A review of our Lancet Oncology data on metabolic risk factors and cancer incidence, and what it means for primary care screening and referral.

February 2025 · 7 min Read →

For Patients

Understanding Your Condition & Your Options

Plain-language guides written with patient representatives — honest, clear, and free from unnecessary jargon.

For Patients

What to Expect When Joining a Clinical Trial

A plain-language guide covering informed consent, safety monitoring, your rights as a participant, what happens at each visit, and how to ask the right questions.

May 2025 · 5 min Read →

For Patients

CLL and SLL: Understanding Your Diagnosis and Treatment Options

An accessible explanation of chronic lymphocytic leukaemia and small lymphocytic lymphoma — what the diagnosis means, how treatment works, and what newer therapies like ibrutinib do.

April 2025 · 6 min Read →

Questions to ask your doctor about clinical trials

For Patients

Questions to Ask Your Doctor About Clinical Trial Participation

A downloadable checklist of questions to bring to your next oncology or haematology appointment — helping you have an informed conversation about trial eligibility.

March 2025 · 3 min Read →

Monthly Briefing

The KCLG Medical Clinical Intelligence Briefing

Each month we curate the most clinically relevant trial updates, methodology commentaries, and evidence summaries — distilled into a single, readable briefing. Trusted by NHS consultants, academic investigators, and specialist nurses across the UK.

Subscribe to the Monthly Briefing

For healthcare professionals and researchers. No spam. Unsubscribe at any time.